28 remedies, honestly labeled.
Every entry is tagged by tier of evidence — from controlled trials to folk tradition. Filter by ailment or search by name.
Curcumin
Indian Ayurveda
The yellow polyphenol of turmeric. Hundreds of trials show anti-inflammatory effects rivaling NSAIDs for osteoarthritis, with emerging anticancer signal.
Psilocybin
Indigenous ceremonial use, Mesoamerica
Phase II/III trials at Johns Hopkins, NYU, and Imperial College show single-dose psilocybin produces rapid and durable remission of treatment-resistant depression and end-of-life anxiety.
Saffron
Persian traditional medicine
Multiple double-blind RCTs show 30 mg/day of saffron extract matches the antidepressant effect of fluoxetine and imipramine for mild-to-moderate depression.
Lion's Mane Mushroom
East Asian traditional medicine
Contains hericenones and erinacines that cross the blood-brain barrier and stimulate nerve growth factor (NGF). Small trials show cognitive improvement in mild dementia.
Methylene Blue
First synthetic drug, 1876
An old industrial dye repurposed as a mitochondrial enhancer. Low doses are being studied for Alzheimer's, frontotemporal dementia, and treatment-resistant depression.
Low-Dose Naltrexone (LDN)
Bernard Bihari, NYC, 1980s
An opioid antagonist at 1/10th the addiction-treatment dose. Off-label use spans Crohn's, MS, fibromyalgia, and adjuvant cancer care.
High-Dose Vitamin D3 + K2
Sunlight; modern megadosing — Cicero Coimbra, Brazil
Maintaining serum 25(OH)D above 50 ng/ml is associated with 25–40% lower cancer incidence. The Coimbra protocol uses much higher doses for autoimmune disease.